The development of therapies with specific molecular or genetic targets, which inhibit growth-promoting signals from classic endocrine hormones (primarily estrogens for breast cancer and androgens for prostate cancer) are now called hormonal therapies. The connotation of the word chemotherapy excludes more selective agents that block extracellular signals ( signal transduction). The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms ( palliative chemotherapy). (4):CD004421, 2007.Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs ( chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Taxanes for adjuvant treatment of early breast cancer. Ferguson T, Wilcken N, Vagg R, Ghersi D, Nowak AK.Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials. De Laurentiis M, Cancello G, D’Agostino D, et al.Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials. for the Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). ![]() § Combined results from 13 randomized clinical trials that together included 22,903 women References ‡ Absolute improvement in survival after 8 years was 3% † Combined individual data from 44,000 women in 33 randomized clinical trials * Combined individual data from 18,000 women in 20 randomized clinical trials Study selection criteria: Early Breast Cancer Trialists’ Collaborative Group pooled analysis and other pooled and meta-analyses.Ībsolute Improvement in Survival with Chemotherapy Containing AnthracyclineĮarly Breast Cancer Trialists’ Collaborative Group *Ĭhemotherapy with an Anthracycline Plus a TaxaneĪbsolute Improvement in Survival with Chemotherapy Containing a TaxaneĮarly Breast Cancer Trialists’ Collaborative Group † Learn about the strengths and weaknesses of different types of studies. Learn more about treatment for HER2-positive early breast cancers. Studies have shown adding a taxane drug to chemotherapy with an anthracycline increases 5-year overall survival. ![]() Taxane chemotherapy drugs used to treat early breast cancer are: Chemotherapy with an anthracycline plus a taxane They found drug combinations containing an anthracycline improved overall survival (about 3% at 5 years and 4% at 10 years). The Early Breast Cancer Trialists’ Collaborative Group combined the results of 17 randomized clinical trials that compared chemotherapy combinations with and without an anthracycline drug. ![]() Chemotherapy with an anthracyclineĪnthracycline chemotherapy drugs used to treat early breast cancer are: Introduction: Many chemotherapy drug combinations can be used to treat early breast cancer. However, to get the most out of the tables, it’s important to understand some key concepts. Summary tables are a useful way to look at the science behind many breast cancer guidelines and recommendations. This summary table contains detailed information about research studies.
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